We are aware that some of our patients taking Hormone Replacement Therapy (HRT), are considering taking We are aware that some of our patients taking Hormone Replacement Therapy (HRT), are considering taking Mounjaro/Wegovy. HRT tablets (especially progestogens like Utrogestan) might become less effective because they slow stomach emptying, affecting absorption. It's crucial to discuss this with the clinician/pharmacy who will be prescribing the injections, (not your GP) - who may recommend switching to non-oral HRT (patches, gels, Mirena coil) or adjusting doses to ensure womb lining protection and symptom control.. HRT tablets (especially progestogens like Utrogestan) might become less effective because they slow stomach emptying, affecting absorption. It's crucial to discuss this with the clinician/pharmacy who will be prescribing the injections, (not your GP) - who may recommend switching to non-oral HRT (patches, gels, Mirena coil) or adjusting doses to ensure womb lining protection and symptom control.